Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology

S Whittle; C Bartholomeusz; M Yücel; M Dennison; N Vijayakumar; NB Allen

Journal article

Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology

S Whittle, C Bartholomeusz, M Yücel, M Dennison, N Vijayakumar, NB Allen

Social Cognitive and Affective Neuroscience | Published : 2014

DOI: 10.1093/scan/nss126

Abstract

There are marked individual differences in the pattern of cortical (sulcogyral) folding in the orbitofrontal cortex (OFC), and there is a growing literature suggesting that these individual differences are associated with risk for psychotic disorders. To date, however, no study has investigated whether OFC folding patterns are associated with broader risk factors relevant to a range of psychopathology. This study helps address this knowledge gap by examining whether OFC sulcogyral folding patterns are associated with putative risk factors, specifically affective temperament and psychiatric symptoms, in a large community sample (N = 152) of adolescents. Results showed that the most common pat..

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University of Melbourne Researchers

Sarah Whittle Author

Cali Bartholomeusz Author

Nick Allen Author

Nandita Vijayakumar Author

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Funding Acknowledgements

Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors would like to thank the Brain Research Institute for support in acquiring the neuroimaging data and the families who participated in the study.